Search results for "snp polymorphism"

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Association Study of Genetic Variants in the 14q11 - 14q13 Proteasomal Genes Cluster with Juvenile Idiopathic Arthritis (JIA) in Latvian Population

2009

Association Study of Genetic Variants in the 14q11 - 14q13 Proteasomal Genes Cluster with Juvenile Idiopathic Arthritis (JIA) in Latvian Population The possible role of proteasomes in the development of autoimmune diseases was hypothesised after discovery of the involvement of proteasomal LMP2 and LMP7 subunits in antigene processing. The objective of this study was to determine the association between allelic variants of the genes encoding proteasomal proteins PSME1, PSME2 and PSMA6 and juvenile idiopathic arthritis (JIA) in the Latvian population. One Indel G-4543 CA-4544 →GA and four SNPs related to the PSMA6 gene (A-2486 →G and C-1910 →T, upstream promoter, C-110 →A of promoter, and C-8…

education.field_of_studymedicine.medical_specialtyCandidate genesnp polymorphismMultidisciplinarySciencePopulationQArthritisOdds ratioHuman leukocyte antigenmedicine.diseaseDisease clusterassociation studychromosome 14EndocrinologySynovitisInternal medicineImmunologymedicinejuvenile idiopathic arthritispsma6educationJuvenile rheumatoid arthritisProceedings of the Latvian Academy of Sciences. Section B, Natural Sciences

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